Twenty-four-year-old Jonathan Saddler and 22-year-old James Lane, both of St. Louis, were shot and killed at 4th and Market streets.
19-year-old Jerico Pikal of Blackwell is charged with assault on a law enforcement officer and resisting arrest.
A suspect who fled from a hospital last week has been caught.
Police chase reaches speeds of 100 mph, then ends in a crash.
A police chase ended in minor injuries for eight people on Thursday.
The accident happened in the pre-dawn hours Tuesday.