Cards manager Mike Matheny and pinch hitter Daniel Descalso were ejected in 9th inning after a called strike three.
Chicago made it a rough night for St. Louis starter Lance Lynn.
St. Louis takes game two of series at Wrigley Field, 3-2.
Manager Mike Matheny argued with plate umpire Dan Bellino after the last out, and was ejected.
The Cardinals took three of four from the Cubs and lead the majors with a 47-26 record.