The Columbia Bottom area is left severely damaged after a levee breach cause by recent flooding.
The waterway has crested from Iowa through southern Missouri and Illinois, but it remained above flood stage at many spots Monday.
Nearly $1.5 million in tornado, flood damage in St. Charles County alone.
Nixon was heading to St. Charles County on Friday for an aerial look at the high water and the condition of levees.
The National Weather Service said the river had crested in the St. Louis area and the Illinois towns of Grafton and Alton further north.
Missouri Senator Roy Blunt says the federal government has gotten too preoccupied with habitat restoration, instead of flood control.
Flooding and concerns about water quality have prompted the closings of several public swimming beaches in Missouri.
The National Weather Service says there are multiple spots of potential failures along that levee between Portage Des Sioux and West Alton.
The rivers appear to have crested.
Warning sirens blared in West Alton Monday night as 590 residents were advised to evacuate because of a levee breach in northeastern St. Charles County.