The two-alarm blaze broke out around 5:30 a-m in the 13600 block of Sturbridge Road.
The fire broke out about 5 a.m. Monday in a small frame home in Berkeley.
Fire officials say a man and his elderly aunt were found dead in the home after the fire Monday evening.
St. Louis firefighters say unattended cooking is to blame.
Five residents burned out of their home. One suffered minor injuries.
City of St Louis firefighters responded to a call of a house in flames, just after noon Saturday.
A car has crashed into a townhome in northern Illinois, rupturing a gas line and setting off an explosion.
The owner says the house, in the 1100 block of Dolman Street, was his childhood home.
11-year-old Maci Gapsch died Wednesday night. Her great-grandmother, Georgette Gapsch and father Terry Gapsch, were also killed in the blaze.
Investigators say the house fire in southwestern Illinois that killed four children is suspicious.