The blaze broke out about 7:30 a.m. at a home on Theodosia near Union.
Tthe fire occurred in the eastern Missouri town of Ste. Genevieve around 4 p.m. Sunday.
John Piper told deputies outside that he was in his bedroom when he heard a loud pop, then he noticed his home was on fire.
Randolph County Coroner Randy Dudenbostel says 45-year-old Dennis Monroe and 42-year-old Willie Monroe were killed in the fire near Sparta on Tuesday.
No injuries were reported.
A neighbor helped two people out of the home while firefighters saved a third person.
Eight people are injured after a Friday morning fire in north St. Louis.
Deceased reportedly include man and his daughter; three other children hospitalized
By late Saturday, police said they’d arrested a suspect.
Major Case Squad says woman’s death was not a homicide.