The truck hit the Third Street bridge, which is just under 15 feet high, and overturned onto its side.
The incident happened around 11 a.m. on I-64 before the Daniel Boone Bridge.
Weekend work completed despite rain.
This Tuesday night MoDOT plans to close westbound I-64 downtown between Jefferson and the Poplar Street Bridge.
Jessica and Kelli Uhl were killed in crash involving state trooper in 2007.
18-year-old Jessica Uhl and 13-year-old Kelli Uhl of Collinsville where killed in a crash blamed on a former Illinois State Police trooper.
MoDOT: If Cards host Washington Sunday, 64 will stay open.
All EB I-64 ramps between Jefferson and PSB will be shut down all weekend.
Again! The Missouri Department of Transportation says westbound I-64 in downtown St. Louis will be closed this weekend.
Two eastbound lanes are expected to remain closed through the evening rush hour.