The $18 million project included the replacement of bridges at Taylor, Newstead, Tower Grove and Boyle, plus construction of a new intersection at Tower Grove and Boyle.
All westbound lanes of Interstate 64 between Forest Park Avenue and Kingshighway will shut down at 9 p.m.
Interstate 64 will close beginning Friday night to remove two bridges in Chesterfield.
Crews will be removing a crane that broke free on the Missouri River that is currently resting on the eastbound truss of the Daniel Boone Bridge.
The Missouri Department of Transportation will close all lanes of I-64 from 8 p.m. on April 4 until 5 a.m. April 7 in two places in the Chesterfield area.
The Missouri Department of Transportation is closing a section of Interstate 64 in St. Louis for the weekend to tear down bridges as part of a project to construct a new interchange.
A burned out trailer smoldered for hours on Interstate 64 during the Friday morning rush.
The St. Louis Mounted Police stables had been shuttered after lead paint was discovered in 2009 but the remediation is now complete, thanks to an endowment from Forest Park Forever.
The Interstate 70 bridge connecting St. Louis County and St. Charles County opened over the weekend, more than 2 months ahead of schedule.
Two people are hospitalized in critical condition.