Drury University is eliminating 35 jobs as enrollment dips at the private Springfield school.
A St. Louis-based Catholic-sponsored health care system is cutting 586 jobs in four states, including 206 in the St. Louis region.
Fire Chief Jason Blackman says they are victims of grant money, about to run out.
The National Emergency Grant will train and re-employment nearly 400 workers throughout Missouri affected by the closure of Hostess Brands Inc.
The layoffs will happen because a three-year, $3.3 million federal grant runs out at the end of March.
Several schools and more than a hundred jobs are on the chopping block as the St. Louis city school district attempts to put forth a balanced budget.
Hundreds of medical students may not be able to start their residency programs in Illinois this summer because of licensing delays.
A battery plant in Maryville, Missouri will be closed in December.
The company considers the cuts permanent.
23 staffers from the newsroom, advertising and production have been laid off.