The departments of Revenue, Agriculture and Financial and Professional Regulation posted draft rules online to address how dispensaries and cultivation centers will be regulated and taxed.
Missouri is looking for other sources of money for education and health care after experiencing shortfalls in gambling and tobacco revenues.
A new report says Missouri revenues are up 2.7 percent through the first three months of the fiscal year from the same period last year.
The head of the Green Party in Illinois, Rich Whitney, says the state needs to capitalize on untapped revenue streams.
The record sales and profits are still short of expectations promised by a private manager that was hired by the state three years ago.
The Missouri Office of Administration says net general revenue through the end of May totaled $7.3 billion.
The Missouri House gave first-round approval Tuesday to a proposed amnesty period that could help delinquent taxpayers pay off their debts while boosting state revenue.
Nixon announced Monday that he is releasing the money to be distributed to higher education institutions.
Figures released Friday by the Office of Administration show net general collections totaled $3.77 billion from July through December.
In addition to the vendors who depend on sales and tips to make ends meet, the city of St. Louis also comes out a loser in the dispute between owners and players.