Shelby Miller struck out eight, all on fastball pitches, allowing two runs and four hits over 6 2-3 innings.
St. Louis was too much for Nationals split squad, 8-1.
The future will only get brighter for Bryce Harper, who has a good chance to develop into a perennial All-Star and MVP candidate.
Cards opening day starter shines in 5-1 exhibition victory over Nationals.
Shane Robinson homered for St. Louis, and Pete Kozma had three hits.
Nationals beat Redbirds 6-2 in first matchup since 2012 NLDS game 5.
According to the statistics, the St. Louis Cardinals historic come from behind victory against the Washington Nationals was not suppose to happen. But the Cardinals have spent much of the last year making the improbable quite possible.
The defending World Series champion Cardinals got a tying two-out, two-run single from Daniel Descalso and a go-ahead two-run single from Pete Kozma in the ninth inning.
St. Louis went 4-0 when facing elimination en route to winning the World Series last year.