The closure beings at 8:30 p.m. Friday. One lane will open at 6 a.m. Saturday.
“After that time there will be no access to St. Charles County from St. Louis County on I-64,” MoDOT’s spokesman Andrew Gates said.
MoDOT’s construction crews are wrapping up other projects.
The warning is out: Interstate lanes and ramps will be closed on both sides of the river in downtown St. Louis.