Initial reports said the entire town of Tiskilwa, which has a population of about 800 had been evacuated.
The train was heading to St. Louis from Chicago.
The accident happened Monday morning in Maplewood.
Two adults, two children in van
One tanker car that was derailed contained a corrosive, but not combustable, chemical.
The Amtrak train was headed to Carbondale with 117 passengers and four crew members.